The Panthers hit the road to take on the Eagles on Saturday afternoon.

The injury bug has bitten South Adelaide again, with three forced changes to the side that faced Glenelg last week.

Jake Arundell broke his arm in the opening minutes of last week's game, which will sideline him for 6-8 weeks.

Max Clifton and Charlie Duncan will also miss due to injury.

See the ProSport Physio Injury list here.

Kobe Mutch fittingly will play his 50th Hostplus SANFL League match against his old side on Saturday.

Oscar Lovelock, brother of Archie Lovelock at Glenelg, is a chance to make his SANFL league debut.

However, the Panthers will be bolstered by the inclusion of Arlo Draper, who returns following a calf complaint.

Scott Bedford, Liam Nye, Tom Wheaton, Darnell Tucker, and Jacob Collins round out the inclusions to the extended squad.

Meanwhile, the Reserves are coming off back-to-back wins and will look to make it three on the trot as they take on the Eagles.

All the action kicks off from 11:30 am followed by the League match at the traditional time of 2:10 pm.

For those unable to attend in person, SANFL Now ensures no moment is missed, with matches streamed live or available on demand across all grades, or via AFL.com.au and the AFL Official Live App on Apple and Android for the SANFL match only.